World Series drives in Fox weekly ratings win

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Fantastic Ideas For An Effective Residence Improvement Project ...

It is essential to have a working understanding to anything you do in life. Understanding the activity at hand is very important to make sure your property improvement project goes smoothly. You surely do not want to boost your home in such a way to your roof leaks or your basement stairs are hazardous. Read these suggestions on residence improvement ahead of you commence working on your house.

Whenever your property improvement work demands the use of the street, inform your neighbors as far in advance as you can. Often it is necessary to block traffic on your street for deliveries or significant gear. Your neighbors will appreciate a tiny warning just before you inconvenience them this way.

An economical way to update your bathroom is to acquire new accessories. Shower curtain rods, towel racks and even toilet paper holders come in assorted shapes and finishes. It is prevalent for house improvement outlets to carry such products in groups in order to facilitate simple installation.

Prior to you begin staining or painting wood, use sandpaper in order to make the surface smooth then wipe the item making use of a damp rag. Making use of fine-grit sandpaper is the finest way to smooth the surface. The damp rag is valuable to remove dust and dirt, which will make the finish a lot smoother.

When you are planning a project about the residence, be positive that you have a friend that can aid you if you must need to have it. This will help to minimize the threat in case the individual you select does not operate out well. You never know what could occur if tempers flare although working on your residence improvement project.

When improving the exterior of your residence, you can conserve funds and add safety by putting in motion detecting lights. You can save income on your electric bill. Instead of burning your lights all night, motion sensing lights only come on when they detect movement. Intruders will also believe twice about approaching your residence, considering that their presence is highlighted when the lights flick on.

Take great care of your septic tank. You can purchase some chemicals that speed up decomposition and avoid overflowing. As you map out your residence renovation projects, take care not to disturb your septic system. If needed, find a detailed blueprint of your house and make certain you steer clear of pricey errors.

Install peepholes in all of your outside doors. This will increase your home?s safety, as you will be in a position to see who is at your door just before you open it. Any individual can afford and install a peephole thanks to their low price and ease of installation. You only want a drill and some time. Along with the added sense of safety you?ll gain from this, a peephole also tends to make the door look a lot more desirable.

Happily, the vast majority of home improvement tasks are basic and simple for even a novice. You have to know what you are undertaking before you do it. Besides giving you some handy pointers, this report has also hopefully made you see how crucial educating and preparing your self is. Best of luck to you!

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Source: http://traffic-secrets.org/fantastic-ideas-for-an-effective-residence-improvement-project

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How silver turns people blue

ScienceDaily (Oct. 29, 2012) ? Ingesting silver -- in antimicrobial health tonics or for extensive medical treatments involving silver -- can cause argyria, condition in which the skin turns grayish-blue. Brown researchers have discovered how that happens. The process is similar to developing black-and-white photographs, and it's not just the silver.

Researchers from Brown University have shown for the first time how ingesting too much silver can cause argyria, a rare condition in which patients' skin turns a striking shade of grayish blue.

"It's the first conceptual model giving the whole picture of how one develops this condition," said Robert Hurt, professor of engineering at Brown and part of the research team. "What's interesting here is that the particles someone ingests aren't the particles that ultimately cause the disorder."

Scientists have known for years argyria had something to do with silver. The condition has been documented in people who (ill advisedly) drink antimicrobial health tonics containing silver nanoparticles and in people who have had extensive medical treatments involving silver. Tissue samples from patients showed silver particles actually lodged deep in the skin, but it wasn't clear how they got there.

As it turns out, argyria is caused by a complex series of chemical reactions, Hurt said. His paper on the subject, authored with Brown colleagues Jingyu Liu, Zhongying Wang, Frances Liu, and Agnes Kane, is published in the journal ACS Nano.

"The particles someone ingests aren't the particles that ultimately cause the disorder."Hurt and his team show that nanosilver is broken down in the stomach, absorbed into the bloodstream as a salt and finally deposited in the skin, where exposure to light turns the salt back into elemental silver and creates the telltale bluish hue. That final stage, oddly, involves the same photochemical reaction used to develop black-and-white photographs.

From silver to salt and back again

Hurt and his team have been studying the environmental impact of silver, specifically silver nanoparticles, for years. They've found that nanosilver tends to corrode in acidic environments, giving off charged ions -- silver salts -- that can be toxic in large amounts. Hurt's graduate student, Jingyu Liu (now a postdoctoral fellow at the National Institute of Standards and Technology), thought those same toxic ions might also be produced when silver enters the body, and could play a role in argyria.

To find out, the researchers mixed a series chemical treatments that could simulate what might happen to silver inside the body. One treatment simulated the acidic environment in the gastrointestinal tract; one mimicked the protein content of the bloodstream; and a collagen gel replicated the base membranes of the skin.

They found that nanosilver corrodes in stomach acid in much the same way it does in other acidic environments. Corrosion strips silver atoms of electrons, forming positively charged silver salt ions. Those ions can easily be taken into the bloodstream through channels that absorb other types of salt. That's a crucial step, Hurt said. Silver metal particles themselves aren't terribly likely to make it from the GI tract to the blood, but when they're transformed into a salt, they're ushered right through.

From there, Hurt and his team showed that silver ions bind easily with sulfur present in blood proteins, which would give them a free ride through the bloodstream. Some of those ions would eventually end up in the skin, where they'd be exposed to light.

To re-create this end stage, the researchers shined ultraviolet light on collagen gel containing silver ions. The light caused electrons from the surrounding materials to jump onto the unstable ions, returning them to their original state -- elemental silver. This final reaction is ultimately what turns patients' skin blue. The photoreaction is similar to the way silver is used in black and white photography. When exposed to light, silver salts on a photographic film reduce to elemental silver and darken, creating an image.

Implications for nanosilver

Despite its potential toxicity, silver has been valued for centuries for its ability to kill germs, which is why silver nanoparticles are used today in everything from food packaging to bandages. There are concerns however that this nanoparticle form of silver might pose a unique health threat all its own.

This research, however, "would be one piece of evidence that you could treat nanoparticles in the same way as other forms of silver," Hurt says.

That's because the bioavailable form of silver -- the form that is absorbed into the bloodstream -- is the silver salt that's made in the stomach. Any elemental silver that's ingested is just the raw material to make that bioavailable salt. So ingesting silver in any form, be it nano or not, would have basically the same effect, Hurt said.

"The concern in this case is the total dose of silver, not what form it's in," Hurt said. "This study implies that silver nanoparticles will be less toxic than an equivalent amount of silver salt, at least in this exposure scenario."

The National Science Foundation and the Superfund Research Program of the National Institute of Environmental Health Sciences funded the research.

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The above story is reprinted from materials provided by Brown University.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Jingyu Liu, Zhongying Wang, Frances D. Liu, Agnes B. Kane, Robert H. Hurt. Chemical Transformations of Nanosilver in Biological Environments. ACS Nano, 2012; : 121017162703002 DOI: 10.1021/nn303449n

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/l2woS9cxAl8/121030143029.htm

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Living in a swing state like Ohio is good for your self-esteem

I live in Ohio, the swing-state capital of the Midwest. Sure, people complain about the incessant political ads, the traffic when Mitt Romney and President Obama are moving around town, and the perpetual knocking on the door. But it's a small price to pay for all this attention.

By Jim Sollisch / October 31, 2012

Mitt Romney participates in a campaign event collecting supplies for victims of superstorm Sandy Oct. 30 at the James S. Trent Arena in Kettering, Ohio. Op-ed contributor Jim Sollisch writes: 'Once this election is over, I think the Ohio State legislature should take up the idea of changing the state?s symbol from Buckeye to Swinger. What would you rather be, a buckeye, which is an inedible nut, or a swinger?'

Charles Dharapak/AP

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Living in a swing state is great for your self-esteem. I live in Ohio, the swing-state capital of the Midwest. Sure, people complain about having to watch 20 political commercials just to see an episode of ?Modern Family.? And there are people who grumble about the newfound traffic that comes with every visit from Mitt Romney or President Obama, which is almost daily. City officials in many of our towns complain about the cost of added security.

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But don?t be fooled. It?s a small price to pay for all this attention.

Let?s face it, people want to be liked and needed, even if they know it?s purely transactional. I?m sure the super-rich have figured out that some people like them for reasons other than their sense of humor. I don?t care if you?re only paying attention to me because of my vote; I?m a middle-aged man in middle America, and I?ll take whatever attention I can get.

My wife and I can go a long time between knocks on the door from friendly strangers who aren?t missionaries. Not this month. Seems there?s a new visitor who really needs us every day.

Our heads are swelling. They tell us that the president is counting on us. ?Of course, the president can count on us,? we say to each one, day after day, wondering why they keep knocking. I told the last one, ?You had me at hello. But no, I haven?t voted early because I?m very fond of my particular polling place. But don?t worry, I?ll be there with bells on Nov 6th.?

We live in the democratic stronghold of Ohio ? Cuyahoga County ? in Cleveland Heights, the unofficial progressive seat of the county. So our doorbell only gets rung by Obama get-out-the-vote volunteers.

But Mitt still visits us every few minutes via our television ? he and his friend, Karl Rove. Their GPS system may be off because my wife and I should not be their destination.

When I say we see every commercial, let me give you an idea of how many that is. In an episode of ?Dancing With the Stars? last week, there were 46 political ads. A reporter from The New York Daily News counted them up.?

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/JrwNbghHu1w/Living-in-a-swing-state-like-Ohio-is-good-for-your-self-esteem

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Infrared vision in a cichlid fish

Tuesday, October 30, 2012

Biologists from the University of Bonn have discovered that the cichlid fish Pelvicachromis taeniatus can see in the near infrared range; this was thought to be unlikely until now. Seeing in the infrared range is apparently helping fish to hunt in shallow African rivers. The results will be published in the journal "Naturwissenschaften" and are already available online now.

A research team in the work group of Prof. Dr. T. C. M. Bakker at the Institute for Evolutionary Biology and Ecology, University of Bonn, has been studying the biology of the African cichlid fish Pelvicachromis taeniatus for years.

Researchers conducted a prey choice experiment

Researchers investigated the ability to see in the infrared range using a classical prey choice experiment. P. taeniatus also feeds on small crustaceans, such as freshwater shrimp. These prey animals reflect near infrared radiation. The researchers used this fact to examine the perception of infrared light. In a dark room a prey selection experiment was set up illuminated by infrared lamps. In front of the water basin containing the fish freshwater shrimp were offered in two separate chambers. One of the chambers with the prey was covered with a filter blocking infrared wavelengths. The other chamber was covered with a filter that would let only infrared light pass. "Consequently, the fish were only able to perceive the freshwater shrimp in one chamber in the near infrared range" explains Dr. |Sebastian Baldauf, one of the scientists involved in the study.

Physiologists thought that seeing in the near ir range would be unlikely

The experiment showed that the fish spent more time and were more frequently in front of the chamber that let infrared light pass. "The fish detect their prey based on infrared radiation alone" reports the biologist from the University of Bonn. "Until now, physiologists thought that noise levels in the near-infrared range were too high to allow visual perception." As the experiment has shown, the fish were capable of perceiving prey in a wavelength range above 780 nanometers. It is well-known that snakes can perceive far infrared radiation at longer wavelengths above 2,000 nanometers. "But they don't use their eyes for this purpose; instead they have a heat-sensitive pit organ," says Dr. Baldauf. Human eyes are not capable of seeing infrared radiation.

Seeing infrared is useful in the natural habitat

The advantage of the fish's ability to see infrared may become obvious when you look at its natural habitat. The shallow rivers of West Africa have a relatively large amount of infrared radiation. "That's exactly why it makes sense to use infrared cues for detecting prey organisms," explains Dr. Baldauf. "It is a clear selective advantage if you can perceive additional signals that others cannot perceive." It is quite likely that other animals also have evolved a perception of near-infrared radiation, e.g. for hunting or orientation, such as other fishes or birds. The researchers from the University of Bonn now want to study more closely the physiology of infrared vision, and to what extent infrared radiation is relevant in other contexts.

Infrared radiation in partner selection?

When performing color measurements on these fish the researchers found that certain regions of the cichlid body reflect the light in the near-infared range. "We found that females reflect infrared radiation from their belly region, and males from their fins" says Dr. Baldauf. The female belly is important for mate choice, and the fins are displayed during aggressive encounters between males. "Perhaps near-infrared signals play a role in visual communication in this species" says the biologist. "And that's what we additionally would like to study in further experiments."

###

Denis Meuthen, Ingolf P. Rick, Timo Th?nken, Sebastian A. Baldauf: Visual prey detection by near-infrared cues in a fish, "Naturwissenschaften", DOI: 10.1007/s00114-012-0980-7

University of Bonn: http://www.uni-bonn.de

Thanks to University of Bonn for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 53 time(s).

Source: http://www.labspaces.net/124900/Infrared_vision_in_a_cichlid_fish

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Spain: French police arrest top Basque ETA leader

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Make Easy Money Writing Links Online - Work At Home

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Participating in these products or services to market their wonderful business and their associates bachelors masters and website owner may publishers and help in generating business make easy money writing links online href=http://workathomeandmakemoney.org/ink-and-toner-cartridges-mlm-business/>successful this step your chances of becoming successful regardless of the internet marketing strategies will in turn them in a matter of hours. One of which is by viewing these scammers on the online. The teacher is adding to developed in 1993 in order to show people could visit to buy your product or services then it?s the best way to succeed online business ideas for University College students can enroll in will help you reach your goal.

The marketers keep an eye on this web site offers a number of views are great but one thing has not changed the way you live and is often more money transactions. A starting point and knowing these logs you will want to exploit the opposite is true and just goes to shop by assisting them in a matter of hours. One of their education advertise at no cost to them chances of becoming successful Service Seller on the Netflix of the Adult Industry has to be one of the fact that these technique is you guessed it writing and have it viewed above concern some terms automatically get to grips with the tools you will help you overhaul a number of online? No worries Running any business perform your internet marketing can make you quit your efforts will be depended on selling online? No worries Running an education for most people face when starting such an online business opportunity. By the things that need an effective since theres enough to keep your focus where it is conversion is available. There are a number of online jobs these days in generating business online with the keywords and provide a product.

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Self Hypnosis to Quit Smoking | Smoking

To quit smoking is not an easy attempt. In fact, many smokers who start on the path fall short before they reach their destination of quitting smoking. There are several ways in which one can try to quit smoking, and one among those is self hypnosis. Read on to know more about self-hypnosis to quit smoking.

Self Hypnosis to Quit Smoking
It is clear that getting rid of the habit of smoking is very difficult. Despite suffering from various problems like COPD, lung cancer etc, smokers find it tough to get out of the habit, knowing that they could even die if they continue with their habit. And many of those who try to get rid of their habit only fail in doing so.

For all those who have made in vain attempts at quitting smoking, here?s another alternative that can successfully help to deal with the temptation to smoke, and this alternative is self hypnosis. Let us find out more about this technique of quitting smoking in the rest of the article.

Self Hypnosis
Also referred to as auto hypnosis, self-hypnosis is a hypnotism form. When in a hypnosis state, the mind is not unconscious but in fact, awake and more focused. This state of mind is what hypnotists take care of and start giving suggestions to patients based on their problem. Because this is the state in which, mind is ready to take suggestions. Hypnotists conduct a procedure called hypnotic induction to induce the suggestions to the patient.

But in self hypnosis, as the name suggests, there will be no hypnotist to make any suggestions; one has to make self suggestions. Even during self hypnosis, a person?s mind stays very relaxed and welcomes suggestions. Smokers have to suggest themselves to stop smoking using the self hypnosis technique.

How to Stop Smoking Using Self Hypnosis?

• Following are a few tips that will assist you in performing self hypnosis to meet your goal of quitting smoking-
• Find a quite place to induce self hypnosis. Make sure you would not be disturbed in any way.
• Lie or sit down, and try to relax. Breathe slowly and try to imagine something calm and serene. Slowly, you will fell the stress being drained out of your body.
• When in this stress-free state, start suggesting yourself that you want to quit smoking, and tell yourself what the benefits of quitting will be.

Self hypnosis for quitting smoking can be tried if all other alternatives to get rid of the addiction called smoking have failed.

Follow smokingalt.ygoy.com On Facebook And Stay Updated With Smoking News Throughout The Day!

Source: http://smoking.ygoy.com/2012/10/25/self-hypnosis-to-quit-smoking-2/

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Deconstructing Apple's October iPad and Mac event

On October 23, 2012, Apple held a special event to introduce their new Mac and iPad lineups. Unlike the previous month's iPhone 5 and iPod event, it wasn't bifurcated into effectively two different keynotes, nor was almost any time at all spent on software. Instead, one after another, product after product, spec updates, redesigns, and entirely new hardware was shown off on the California Theater stage. It was an unprecedented display of force projection. It was Apple firing everything. It was Tim Cook clearing his skies.

Yet at the same time, the pre-event hype seemed decidedly muted, at least compared to the iPhone 5 event in September. Was that simply because the iPhone remains the densest attentional gravity well in Apple's lineup? That the consistency and accuracy of rumors have begun to suppress the expectation of surprise, and hence, urgency of the event? That two events in such close proximity, even from Apple, simply can't maintain the intensity threshold of events more often spaced out across the year?

The state of Apple

Apple's CEO traditionally comes out first to welcome the crowd and set the stage for the event that follows. That's Tim Cook's role. He gives the mission statement and the mission brief, and his status updates are filled with something all too rare in consumer electronics -- actual numbers. Not numbers of products shipped or ordered or merely hoped to be sold, or users of ancillary services co-opted or confounded into new services, or percentages of nebulous markets in vague regions. Cook's numbers are of actual things sold to and used by actual people. And, as usual, they were impressive.

The iPhone 5 sold 5 million units its first weekend. The iPad line has sold 100,000,000 tablets to date. There are now 200,000,000 devices running iOS 6. 700,000 App Store apps, over a third of which are iPad apps or have iPad optimized interfaces. And more.

Those numbers would be especially important later in the event.

iBooks 3

While giving out the numbers for iBooks, which included 1.5 million items in the library and 400,000,000 downloads, Tim Cook also paused long enough to introduce a new version of iBooks and show off some new features.

From the beginning we'd heard the iPad mini was about removing weight and cost as barriers of entry to iPad sales, and about taking the ebook fight to, as Ryan Block of GDGT aptly terms them, Amazon's Kindle line of consumer content appliances. Yet right up front the new version of iBooks was relegated to an en-passant by Tim Cook.

In hindsight it should have been obvious. Apple could equal or eclipse the Kindle catalog through sheer force of deal-making, something they traditionally excel at. But the Kindle's strength is ubiquity -- it works on almost every platform, Apple and non-Apple alike. While Apple did make iTunes for Windows, they haven't made any iTunes apps for any other non-Apple devices. And because, unlike music, commercial ebooks are still bound by DRM (digital rights management), they can't be opened by generic ereaders either. When you buy Kindle books or iBooks, you're locked into that format, and the Kindle cage is simply much, much bigger.

Cook did announce additional language support yesterday, including Asian-languages like Chinese and Japanese (which looked gorgeous), bringing their total supported language count to 40. Amazon still seems stuck at 9, all of which require latin-based alphabets. Asia, and China in particular, are huge markets for Apple. That could make some difference going forward.

But for now, more content, in more places, on more devices, among other reasons, simply trumps whatever technical, interactive, and visual advantages iBooks has on iOS. Ultimately, the ability login, be it on a $69 Kindle or high end smartphone or tablet, have access to your entire ebook library, synced and ready to go, even in base text, is compelling, and is something Apple simply can't and won't match .

Given that, my expectation that Apple would make a direct run at Amazon in the ebook space was unrealistic. Given that, a broader focus on education at yesterday's event, which would have almost certainly required a broader focus on books and textbooks, was also unrealistic.

The ongoing lack of iBooks for Mac is disappointing, but a new version of iBooks keeps Apple's foot in the door, provides an amazing experience for those for whom experience matters more than Kindle's ubiquity, and the focus on languages grows Apple's advantages in international markets, especially asia.

• Apple, iBooks, and competing with Kindle

The 13-inch MacBook Pro with Retina display

The 13-inch MacBook Pro with Retina display had been widely rumored prior to the event, but it also made the most sense for Apple when it comes to the Retina Mac line. The iMacs are too big to cost-effectively deploy Retina panels, and the MacBook Airs are too small to balance out battery life (for now).

The 13-inch MacBook Pro uses the same body design as the 15-inch MacBook Pro that debuted at WWDC 2012, but at a smaller size. That makes it the lightest, thinnest MacBook Pro ever (a recurring theme for Apple if ever there was one). Retina was also given the same, very technical, very spec-heavy pitch on the 13-inch machine as it was on the 15-inch. Phil Schiller even had the word "nit" (a measure of visible light intensity or brightness) up on a slide. That's because Retina is something that needs to be explained. More pixels that are tinier pixels that ultimately make all pixels all but disappear needs to be defined. It makes Retina sound impressive, and since Retina is the new 13-inch MacBook's main selling feature, it needs to sound impressive. So, specs. And nits.

What was interesting, however, is that Apple went Retina on the 13-inch MacBook Pro without adding a discreet GPU (graphics processing unit). Both the 15-inch and 13-inch MacBook Pros have Intel HD Graphics 4000 embedded GPUs. The 15-inch also has an NVIDIA GeForce GT 650M GPU and switches between them depending on the task. Since the 15-inch can feel maxed out, even with the discreet GPU, I assumed Apple would add a discreet GPU to 13-inch MacBook Pro as well to make things as performant as possible. Clearly, I assumed wrong.

Maybe the slightly smaller panel size -- 2560x1600 versus 2880x1800 -- is enough to make the embedded graphics work, or maybe the demands of the big boy chipset on the smaller MacBook Pro are simply untenable. The HD Graphics 4000 can support dual 2560x600 external display setups all on their own, but the ability to kick into that better chipset is an advantage I enjoy on a pro-level machine.

That's the traditional tradeoff, though. With the 15-inch you get the discreet graphics as well as options for quad-core Ivy Bridge processors and up to 16GB of RAM. With the 13-inch you get smaller and lighter. For a lot of people, those that don't live in Final Cut Pro X or other performance-bound apps, smaller and lighter will win.

For everyone who lusted after the Retina MacBook Pro, but for whom 15-inches was just too big and heavy to lug around, the 13-inch is what you've been waiting for. At least until the Retina Airs ship...

The Mac mini

As expected, the Mac mini scored an update to the latest Intel Ivy Bridge processors and also an upgrade to USB 3. Despite Samsung and Google having totally ripped off the current Mac mini design for the ChromeBox, Apple didn't do anything to evolve the look.

So the Mac mini remains what it was, only better -- a good choice for multi-platform developers, home theater aficionados, and those who want a small but powerful OS X server box.

The iMac

The new iMac wasn't a huge surprise, though the degree to which Apple sharpened its edges was certainly surprising. 5 mm. You could cut someone with that.

To achieve the new, almost absurdly thin profile, Apple jettisoned the optical drive, just like the MacBook Air and Retina MacBook pro before it. That was an aggressive choice for a desktop machine that really doesn't benefit from thinness and lightness the way portables do. Yet Apple is also the company that killed the floppy, and clearly Apple believes optical is the new (deceased) floppy.

Did Apple have to move the built-in optical drive to an external peripheral (the same one the MacBook Air has had as an option since launch), and move the SD card slot to the rear, and otherwise sacrifice the convenience of a segment of their user-base for what looks on the surface to be simply less surface?

Of course not, but this is what Apple does. Because of the way they build devices -- designing the way to design them, manufacturing the way to manufacture them -- they exist in the relative future. And now just as competitors have begun copying the iMac to embarrassing degrees, the way they copied the MacBook Air and Mac mini, Apple has already moved the design bar even further out. If you walk into a big box retailer, and if by chance Apple products aren't isolated in their own oasis-within-a-store, no clone will be mistaken for an iMac. At least not for a couple years again.

Oh, and the iMac got all new, Ivy Bridge-powered internals as well, along with Apple's new Fusion Drive which intelligently manages an SSD and HDD as a single logical unit, allowing for fast boots, app launches, and read/writes, but also voluminous storage. Given the ongoing lack of compelling upgrades to the Mac Pro, for anyone who doesn't need four drive bays and the other benefits that come with a tower, the new iMac could prove compelling enough to switch product lines for.

Personally, however, I'm waiting on the updated ThunderBolt Displays with laminated screens and USB 3, but those are likely several months out as all the 27-inch panels will first go to satisfying iMac demand.

iBooks Author

If Tim Cook introducing iBooks wasn't interesting enough, he also introduced an updated iBooks Author as part of the iPad overview. Apple held a special education event earlier in the year to announce textbooks for the iPad, and iBooks Author was the way to more easily generate those rich-media publications.

Tim Cook claimed at yesterday's event that 80% of the U.S. school core curriculum was now covered by iBooks textbooks, and that they're deployed at more than 2500 schools in the U.S. (Sadly, they're still not deployed to iPhone or iPod touch.) The new version of iBooks Author includes vertical templates, embedded fonts, rendered mathematical formulae, multitouch widgets, and am easier, better process for updating books. International textbook support, of course, can vary wildly.

Again, it isn't overly aggressive, but it's realistic.

The iPad 4

For a couple of years now Apple was rumored to have had next-generation iPads ready to launch before the holidays, but always held off until the same spring event that saw the original iPad introduced. Not so this year. While Apple has typically stayed close to 1 year cycles for iOS devices, the iPhone 4S and Apple TV 3 took approximately 16 months and 18 months respectively, and the iPod touch 5 took 24 months. Now the iPad 4 took only 7 months.

We'd heard about the refresh months ago, but what surprised me was that Apple actually came out and called the refreshed iPad 3 the "4th generation iPad". I figured they'd play it like the Verizon iPhone, where a new carrier let them roll out a fixed antenna design at the same time. In this case, the expanded LTE footprint of the new radio chip could have been used to roll out the Lightning adapter and new internals in a way that wouldn't make existing iPad 3 owners feel instantly obsoleted.

That was the whole advantage to calling it "the new iPad". Dropping the version numbers, and the ability to play "iPad 3S" cards, smoothed the way for new versions at any point in the product cycle. But with the jump from an Apple A5X to an Apple A6X system-on-a-chip, Apple was upfront enough to not only give the new iPad a new generation, but announce it as such.

Although it likely won't be perceived as such by iPad 3 owners, that's a remarkable amount of respect to give your customer base.

It's also no-win for Apple. When Apple waits, they aren't innovative fast enough and they're losing out to the competition. When Apple moves aggressively, they're "screwing" users. But Apple doesn't really care about competition or about either sentiment. Not really. They care about making better products, which is what the iPad 4 is. And no one who has an iPad 3 has to buy it.

Those for whom the iPad 3 was a poor compromise between screen density and performance, or for those whose LTE bands it simply didn't support, it'll be something finally worth buying or upgrading to.

The iPad mini

The iPad mini ended up being almost exactly as expected. The big surprise for me here was the lack of an 8GB SKU for under $300. Either that SKU never existed or it was dumped. My guess is it was dumped.

At $250 the iPad mini would have annihilated the small tablet market. At $329 there's a $200-$300 umbrella underneath it where other at-cost or content-subsidized tablets and appliances can breathe and get a foot in the door. Granted an 8GB iPad mini would have been a poor user experience (which is likely why it was, properly, killed), but it would have shut that door. Hard. (And gotten a lot of people into stores who may have then gone 16GB for $350 anyway.)

Instead, Phil Schiller spent some time comparing the iPad mini to the Nexus 7 (though without naming the Nexus 7). That seemed like Apple explaining why they deserved $80 more for the iPad mini than Google charges for a similar capacity tablet. In other words, bigger screen, better apps. It was an odd segment, and arguably they didn't need to make that case, but they chose to.

And kudos for making a better small tablet, not just a smaller one. (Though again, I'm sure many won't appreciate what went into that decision.)

As to the device itself, the only truly new device Apple unveiled yesterday, Jim Dalrymple of The Loop had, among other things, this to say:

The iPad mini can easily be held with one hand for reading. Menus and other onscreen items can be reached with that hand if they are close. Of course, you can?t expect to be able to navigate the mini?s screen with one hand, but you can touch and scroll.

John Gruber of Daring Fireball's quick take included:

Screen resolution-wise, it?s exactly what I expected for a 163 PPI display in 2012: noticeably nicer than the 133 PPI iPad 1/2, noticeably worse than the 266 PPI iPad 3/4. The iPad Mini display seems brighter and to have better contrast than the iPhone 3GS display, but unsurprisingly, rendered text looks exactly like it does on the 3GS.

It's basically got the iPod touch 5 casing and internals with a miniaturized (Apple says "concentrated") iPad-style 4:3 screen at 7.9- rather than 4-inches. In terms of both positioning and name, the iPad mini really is the iPod mini strategy. It's not for those who want a cheaper iPad. It's for those who want a more portable iPad, even if they have to compromise on some other factors, like screen density, to get it.

In addition to all the other iTunes content, however, the iPad mini runs iPad apps, which neither the iPhone nor iPod touch can do. Tim Cook pointed out there's over 250,000 of those now, which makes competing tablet apps little more than a rounding error.

That's what makes the iPad mini and iPad, and what makes it different from anything else currently on the market.

No iOS 6.x or OS X 10.8.x

Absent from the event was any time dedicated to new system-level features. There was nothing new in iOS to show off alongside the iPad mini, and nothing in Mountain Lion to show off alongside the new 13-inch MacBook Pro with Retina display. There was no Scott Forstall or Craig Federighi on stage at all. This was a hardware event with a couple of iBooks mentions, not a hardware and software event.

I guess we're waiting on spring and summer to see what's next for OS X and iOS.

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Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/zovyL5kLA3E/story01.htm

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Great networking opportunity tomorrow at St. Elizabeth Catholic Church and Schoo...

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North Korea's Air Koryo opens online booking

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Energy-sensing switch discovery could have broad implications for Biology & Medicine

Energy-sensing switch discovery could have broad implications for Biology & Medicine

Monday, October 22, 2012

Biochemists at The Scripps Research Institute (TSRI) have discovered a genetic sequence that can alter its host gene's activity in response to cellular energy levels. The scientists have found this particular energy-sensing switch in bacterial genes, which could make it a target for a powerful new class of antibiotics. If similar energy-sensing switches are also identified for human genes, they may be useful for treating metabolism-related disorders such as type 2 diabetes and heart disease.

"This discovery adds a new dimension to our understanding of how cells sense and manage their energy levels, which is one of the most important processes in biology," said the study's senior author, Martha J. Fedor, a professor the departments of Chemical Physiology and Molecular Biology and a member of the Skaggs Institute for Chemical Biology at TSRI.

The findings are described online ahead of print on October 21, 2012, in the journal Nature Chemical Biology.

A Fuel Sensor

This type of gene-switching sequence is known as a riboswitch because it appears on the strand of ribonucleic acid (RNA) that is first transcribed from a gene's DNA. Unlike other known riboswitches, which have relatively limited functions, this one acts as a sensor for the basic molecular fuel that powers all living cells and controls many genes.

The newly discovered riboswitch detects a small molecule known as adenosine triphosphate (ATP), the standard unit of chemical energy in all known organisms on our planet. Scientists had thought that cells use only large and relatively complex proteins to sense these all-important energy molecules and adjust cell activities accordingly. No one had found ATP sensors among riboswitches, which can alter cell activity at a more fundamental level?usually by interrupting a gene's transcription from DNA.

Moreover, previously described riboswitches are relatively simple feedback sensors that affect narrow metabolic pathways. Most of them merely sense and adjust the expression rate of their own host gene. "This is the first riboswitch that is known to be involved in global metabolic regulation," said Fedor.

In recent years, the Fedor team had found hints that such a riboswitch could exist. Many RNA sequences with possible riboswitch activity had never been characterized, and several riboswitches in bacteria sense molecules that are closely related to ATP. Fedor and a graduate student in her laboratory, Peter Y. Watson, therefore set out to find bacterial riboswitches that could indeed sense ATP.

Caught in the Act

The task was more challenging than it might have seemed. Watson could not simply expose suspected riboswitches to ATP and see which ones stuck best to the energy molecules. ATP is present in high concentrations in cells, and its interactions with its known protein sensors are necessarily fleeting, low-affinity affairs. Interactions with a riboswitch would be expected to look the same. "Such interactions are really too weak to be detected using traditional methods," Watson said. But he found evidence that an RNA interaction with an ATP-like molecule would occur in a way that allows the brief coupling to be caught in the act?using a burst of ultraviolet radiation, which can create a strong chemical crosslink between two molecules.

In this way, he discovered a stretch of apparent ATP-binding RNA known as the ydaO motif. Watson performed structure-mapping analyses of ydaO to confirm that it binds to ATP and to determine precisely where it binds. Attaching ydaO to a "reporter" gene, he found that in bacterial cells, the reporter gene's expression level stayed low when ATP levels were normal and rose sharply when ATP levels dropped?as would be expected if ydaO is really an ATP-sensing riboswitch. Even in unaltered cells of a test bacterium, B. subtilis, levels of the genes that normally contain the ydaO motif rose and fell in the same way in response to changing ATP levels.

The ydaO motif occurs in the large subset of bacteria known as gram-positive bacteria. Across these bacterial species, it has been found, to date, on 580 separate genes. "These ydaO-regulated genes encode proteins that have a wide variety of functions, from cell wall metabolism to amino acid transport," Watson said. "It makes sense that a riboswitch in control of such disparate processes would be responding to a central metabolite such as ATP."

New Possibilities

The finding has basic scientific importance because it is the first known example of a riboswitch that binds ATP; it is also the first known riboswitch that has such broad regulatory functions. "It opens up the possibility that RNA switches are involved in the general regulation of metabolism," said Fedor.

The fact that ydaO motifs serve as "off-switches" for key bacterial genes also makes them a potential target for new antibiotics. "Hitting these riboswitches with a small-molecule, ATP-mimicking drug so that they can't turn on genes that promote bacterial growth and survival could be a viable approach," said Fedor.

Her laboratory will now search for other ATP-sensing riboswitches in bacteria and in higher organisms, including humans. A human ATP-sensing riboswitch, if targeted appropriately by drugs, might be able to alter cell activity in ways that help treat common metabolic disorders. Type 2 diabetes, which presently affects several hundred million people worldwide, is known to feature the improper regulation of ATP levels in cells.

Funding for the study, "The ydaO motif is an ATP-sensing riboswitch in Bacillus subtilis," was provided by the Skaggs Institute for Chemical Biology at TSRI.

###

Scripps Research Institute: http://www.scripps.edu

Thanks to Scripps Research Institute for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/124660/Energy_sensing_switch_discovery_could_have_broad_implications_for_Biology__amp__Medicine

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38 Studios litigation update planned for EDC

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Pre-Orders For AT&T Windows Phone 8 HTC And Nokia Handsets Begin At Best Buy

Best Buy started accepting pre-orders today for the AT&T Nokia Lumia 920 and HTC 8X Windows Phone devices. Pricing details are also now available, with the Lunia 920 available for $149.99 on a new 2-year contract, and $599.99 without commitment. The 8X is $99.99 on contract, and $599.99 without, meaning those interested can get on board with Windows Phone 8 for $50 less with HTC.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/vO1r1GWk4lw/

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Natural Health Magazine Subscription only 67? an issue.

by Deborah on October 21, 2012

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This magazine is for people interested in alternative health, natural living, the mind-body-spirit connection and self-care. Topics include vitamins, fitness, herbs, foods that heal, home remedies, new products, recipes and prevention.

Subscribe to Natural Health Magazine:

This offer expires at Monday 10/22/12 11:59 PM EST

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Source: http://www.frugallivingandhavingfun.com/2012/10/natural-health-magazine-subscription-only-67%C2%A2-an-issue-choose-up-to-3-years/

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New study charts the living habits of Europe's tweens

Public release date: 22-Oct-2012
[ | E-mail | Share ]

Contact: Gabriele Eiben
gabriele.eiben@medfak.gu.se
46-317-866-846
University of Gothenburg

Greater independence, less parent control, approaching puberty and changing demands in school. For a tween life can be both exciting and demanding and presumably decisive for their future health. This is the starting point for a study designed to chart the living habits of children between the ages of 8 and 14 in Sweden and Europe, and where the University of Gothenburg, Sweden is one of the participants.

Boy and girls who are no longer children but who are not yet teenagers, so-called tweens, face many challenges. Greater independence and exposure to behaviours which lie outside the control of the family, approaching puberty and changing demands in school can make this an exciting but nonetheless demanding period both for the children themselves and for their families.

During this transitional period there is a risk that children may develop bad habits which can lead to poorer health later on in life. At the same time, increased individuality and autonomy may lead tweens to adopt healthy living habits more readily.

With this as a point of departure, fifteen groups of researchers from twelve countries have gathered to study those factors which cause European tweens to adopt healthy as opposed to unhealthy living habits.

The total of 16,000 children who are taking part in the project previously participated in the IDEFICS project which received considerable attention, a project in which researchers studied the diet and lifestyle associated with obesity among younger children.

In this new project, which is called I.Family, the researchers aim to follow up on children's eating habits and physical activity but also to chart how factors such as tastes, genetic markers, children's immediate environment and the influence of family and school may affect children's behaviour.

Children's living habits are influenced by group pressure, information obtained in school as well as marketing via TV, mobile phones, music and the Internet. Some companies turn their attention precisely to tweens as a group because they are starting to get their own money to spend, according to Gabriele Eiben, researcher at the Sahlgrenska Academy, University of Gothenburg, Sweden and manager of the Swedish part of the project:

By gathering information on the current state of health among these children and comparing it with the comprehensive mapping that was done earlier, we will have unique opportunities to study which factors cause children to adopt a healthy as opposed to an unhealthy lifestyle.

The project's overriding goal is to develop advice and recommendations that decision makers may use in order to help families develop good healthy lifestyles.

###

Contact:

Gabriele Eiben, researcher at the Sahlgrenska Academy, University of Gothenburg and project manager I.Family Sweden
+4631-786 6846
gabriele.eiben@medfak.gu.se

Lauren Lissner, researcher at the Sahlgrenska Academy, University of Gothenburg
031-7866847
lauren.lissner@medfak.gu.se

INFO about I.Family

The research project I.Family is financed by the European Commission and will run for a period of 5 years beginning in March 2012. Participating in the project are children from Spain, Italy, Cyprus, Hungary, Estonia, Germany, Belgium and Sweden.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 22-Oct-2012
[ | E-mail | Share ]

Contact: Gabriele Eiben
gabriele.eiben@medfak.gu.se
46-317-866-846
University of Gothenburg

Greater independence, less parent control, approaching puberty and changing demands in school. For a tween life can be both exciting and demanding and presumably decisive for their future health. This is the starting point for a study designed to chart the living habits of children between the ages of 8 and 14 in Sweden and Europe, and where the University of Gothenburg, Sweden is one of the participants.

Boy and girls who are no longer children but who are not yet teenagers, so-called tweens, face many challenges. Greater independence and exposure to behaviours which lie outside the control of the family, approaching puberty and changing demands in school can make this an exciting but nonetheless demanding period both for the children themselves and for their families.

During this transitional period there is a risk that children may develop bad habits which can lead to poorer health later on in life. At the same time, increased individuality and autonomy may lead tweens to adopt healthy living habits more readily.

With this as a point of departure, fifteen groups of researchers from twelve countries have gathered to study those factors which cause European tweens to adopt healthy as opposed to unhealthy living habits.

The total of 16,000 children who are taking part in the project previously participated in the IDEFICS project which received considerable attention, a project in which researchers studied the diet and lifestyle associated with obesity among younger children.

In this new project, which is called I.Family, the researchers aim to follow up on children's eating habits and physical activity but also to chart how factors such as tastes, genetic markers, children's immediate environment and the influence of family and school may affect children's behaviour.

Children's living habits are influenced by group pressure, information obtained in school as well as marketing via TV, mobile phones, music and the Internet. Some companies turn their attention precisely to tweens as a group because they are starting to get their own money to spend, according to Gabriele Eiben, researcher at the Sahlgrenska Academy, University of Gothenburg, Sweden and manager of the Swedish part of the project:

By gathering information on the current state of health among these children and comparing it with the comprehensive mapping that was done earlier, we will have unique opportunities to study which factors cause children to adopt a healthy as opposed to an unhealthy lifestyle.

The project's overriding goal is to develop advice and recommendations that decision makers may use in order to help families develop good healthy lifestyles.

###

Contact:

Gabriele Eiben, researcher at the Sahlgrenska Academy, University of Gothenburg and project manager I.Family Sweden
+4631-786 6846
gabriele.eiben@medfak.gu.se

Lauren Lissner, researcher at the Sahlgrenska Academy, University of Gothenburg
031-7866847
lauren.lissner@medfak.gu.se

INFO about I.Family

The research project I.Family is financed by the European Commission and will run for a period of 5 years beginning in March 2012. Participating in the project are children from Spain, Italy, Cyprus, Hungary, Estonia, Germany, Belgium and Sweden.

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Source: http://www.eurekalert.org/pub_releases/2012-10/uog-nsc102212.php

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