Thursday, October 10, 2013

Particle Fever: Film Review



The Bottom Line


A timely and fascinating look at physicists' search for the Higgs boson.




Opens


March 5, 2014


Director


Mark A. Levinson




A particularly timely work given the Nobel Prizes for Physics just announced for two of its central figures, Particle Fever succeeds on every level, but none more important than in making the normally intimidating and arcane world of genius-level physics at least conceptually comprehensible and even friendly to the lay viewer. This unexpected look at the long run-up to and successful completion of the most elaborate and costly science experiment ever conducted -- the use of the Large Hadron Collider to attempt to find the Higgs boson -- is not only fascinating, but also humanizes the field in a way that will inspire practitioners and provoke the curiosity of non-specialists. Set for theatrical release next March, this top-notch account of a major moment in the advance of human knowledge will have a long, full life in all documentary-friendly arenas worldwide.



It's crucial for starters that the subject is second nature to the filmmakers: director Mark Levinson earned a doctoral degree in particle physics from Berkeley before veering into film, and producer David Kaplan, a professor of theoretical particle physics at Johns Hopkins, has also been active on History Channel and National Geographic science programs. They're able to simplify and synthesize without dumbing down the material and put non-science-oriented viewers at ease by drawing a smart parallel between science and art: Both endeavors ultimately represent attempts to explain our existence and our place in the universe.


PHOTOS: Telluride Film Festival: The Films 


It also doesn't hurt that both the metaphysical and the (literally) physical backdrop for the film is enormous. The Large Hadron Collider (LHC) is the biggest machine ever built. Buried underground in Switzerland, it resembles but dwarfs any set ever built for a James Bond film, measuring seven stories tall and consisting of a 17-mile ring through which protons, powered by seven-ton super-conducting magnetos, will be sent to collide with each other at a speed aimed to reproduce conditions such as those just after the Big Bang.


The Atlas Experiment, which was initiated in the 1980s, involves 10,000 people from 100 countries and the use of 100,000 computers to deal with all the data. An even bigger such machine was started in the United States but was canceled by Congress after a few years because there were no specific military or commercial applications for the experiment. Trying to convey the magnitude of the project, participants compare it to the building of the pyramids or the moon landings, only bigger.


And what is its raison d'ĂȘtre? This is described in many ways: To try to understand the basic laws of nature, to discover the key particle that holds everything together (which is what the Higgs boson describes), to identify particles scientists know are out there but haven't been seen and, in the simplest terms, to learn which group of theorists is correct -- those who believe in the “super-symmetry” of one universe or the adherents of an ever-expanding “multi-verse” based on randomness and chaos.


The LHC will be the vehicle to take physicists to and, they hope, beyond the outer edge of the scientific frontier as currently acknowledged; everyone in the field is keyed up by the certainty that a new threshold is about to be breached. “It's going to change everything,” Kaplan predicts.


With foresight, Kaplan and Levinson began production in 2008 and, while the center of action remains the European Center for Nuclear Research (CERN) in Switzerland, the net is cast wide to encompass the perspectives of scientists as they gather there, as well as those following events with computer links elsewhere. The project leader is an Italian woman, Fabiola Gianotti; an American woman, Monica Dunford, provides an emotionally excitable take; a veteran Greek physicist, Savas Dimopoulos, is concerned that he's too old to be able to take part in what he's sure will be the exciting next phase of research; while Nima Arkani-Hamed, whose family escaped from revolutionary Iran after 1979, has a great deal riding on the experiment, about which he says, “The hype is approximately accurate.”


There is a long delay while a leak in the collider is repaired, giving the filmmakers some downtime to provide some deeper background and an increased sense of what is at stake. What everyone says is coherent, sometimes witty and always interesting, although for a commoner a huge gulf remains between how the ideas of physics are addressed with words and how they are approached via incomprehensible scribbles on a blackboard or piece of paper.


Cut by celebrated film editor Walter Murch to build in momentum in the manner of a strong dramatic feature, Particle Fever imparts a great deal of information while bringing to light a rarefied world defined by intense mutual interests and great camaraderie coupled with inevitable competitiveness. The big split among physicists is between the theorists and the experimentalists, with one bemusedly pointing out that the secret to success in physics lies in “jumping from failure to failure with undiminished enthusiasm.”


On July 4, 2012, the results are finally obtained, to the joy of those assembled at CERN and in other smaller gatherings around the world. Among the crowd packed into the auditorium is aged British physicist Peter Higgs, for whom the elusive particle was named and who is seen removing his glasses and dabbing his eyes. It's a well-earned moving climax to the film, as it's evident that a major frontier has been conquered and new horizons opened up. A clip from Werner Herzog's cave art documentary Cave of Forgotten Dreams is used to again invoke the link between art and science in the search for coherence and meaning. For the more art-minded, seeing such an articulate and clear-headed elucidation by physicists of what they do results in an invigorating new insight into a vital realm of exploratory endeavor.


Venues: Telluride, New York Film Festivals


Opens: March 5, 2014 (Abramorama, BOND Strategy and Influence)


Production: Anthos Media, PF Productions


With: Martin Aleksa, Nima Arkani-Hamed, Savas Dimopolos, Monica Dunford, Fabiola Gianotti, Mike Lamont


Director: Mark A. Levinson


Producers: David E. Kaplan, Mark A. Levinson, Andrea Miller, Carla Solomon


Executive producers: Thomas Campbell Jackson, Gerry Ohrstrom


Directors of photography: Claudia Raschke-Robinson, Wolfgang Held


Editor: Walter Murch


Music: Robert Miller


99 minutes


Source: http://feedproxy.google.com/~r/thr/reviews/allreviews/~3/a8i7RWzklko/particle-fever-film-review-646439
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Monday, April 29, 2013

In 2012, 19 billion chat messages were sent each day across the world?compared to just 17.

In 2012, 19 billion chat messages were sent each day across the world?compared to just 17.6 billion SMS messages.

Read more...

    


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/lZXhirvL56E/in-2012-19-billion-chat-messages-were-sent-each-day-ac-484243111

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Some say immigration bill is bad deal for the GOP

WASHINGTON (AP) ? Some feisty Republicans are challenging a claim widely held among GOP leaders that the party must support more liberal immigration laws if it's to be more competitive in presidential elections.

These doubters say the Republican establishment has the political calculation backward. Immigration "reform," they say, will mean millions of new Democratic-leaning voters by granting citizenship to large numbers of Hispanic immigrants now living illegally in the United States.

The argument is dividing the party as it tries to reposition itself after losing the popular vote in five of the past six presidential elections. It also could endanger President Barack Obama's bid for a legacy-building rewrite of the nation's problematic immigration laws.

Many conservatives "are scared to death" that the Republican Party "is committing suicide, that we're going to end up legalizing 9 million automatic Democrat voters," radio host Rush Limbaugh recently told Sen. Marco Rubio, R-Fla., a leader of the bipartisan team pushing an immigration overhaul.

Strategists in both parties say several factors, including income levels, would make many, and probably most, newly enfranchised immigrants pro-Democratic, at least for a time.

Rubio says the risk is worth taking.

"Every political movement, conservatism included, depends on the ability to convince people that do not agree with you now to agree with you in the future," he told Limbaugh.

Politically, Republicans face two bad options.

They can try to improve relations with existing Latino voters by backing a plan that seems likely to add many Democratic-leaning voters in the years ahead. Or they can stick with a status quo in which their presidential nominees are losing badly among the electorate's fastest-growing segment.

In 2012, Republican presidential nominee Mitt Romney, who suggested that vanishing job opportunities would prompt immigrants to "self deport," carried only 27 percent of the Hispanic vote. A Republican Party study of that election concluded, among other things, that the GOP must appeal to more Hispanics, and to do so it must "embrace and champion comprehensive immigration reform."

Party leaders say the harsh language that some Republicans use when discussing illegal immigration has angered many Americans with Hispanic heritages.

Rubio's bipartisan group has proposed legislation to strengthen border security, allow tens of thousands of new high- and low-skilled workers into the country, require all employers to check their workers' legal status, and provide an eventual path to citizenship for some 11 million immigrants now in the country illegally.

Even if the bill survives the Democratic-controlled Senate, stiff resistance is expected in the GOP-dominated House. Many House Republicans dislike the idea of "amnesty" for those who crossed the border illegally, and some say it's foolish to enfranchise likely Democratic voters.

Obama embraces the Rubio plan, and it won crucial praise from House Speaker John Boehner, R-Ohio, and Rep. Paul Ryan, R-Wis., last year's vice presidential nominee.

Rubio and his allies challenge the notion that creating a way to citizenship for millions of people here illegally will dramatically increase Democratic turnout in future elections.

"Not all 11 million illegal immigrants here today will qualify to become citizens, and not all of the 11 million illegal immigrants are Hispanic," according to Rubio's "Myth vs. Fact" website. The site says many immigrants will not choose to become citizens, and many new citizens, like many current ones, will not bother to vote.

Some Republican campaign strategists, however, say the political damage would be worse than party leaders acknowledge.

Republican consultant and pollster Mike McKenna said one of his surveys shows that most Americans favor "immigration reform" and they believe it will benefit Democrats more than Republicans.

In an interview, McKenna said Republican leaders are embracing Rubio's plan without sufficient data on where it might lead. "I think about two months from now, the folks in the establishment are going to wish they hadn't started this conversation," McKenna said.

Party leaders erred, he said, by couching the immigration debate in political rather than moral terms. "The argument that it's going to be politically advantageous is not going to be sustainable over time," McKenna said.

Political activists have swapped estimates of how many people now living here illegally might choose to become citizens, register to vote and turn out for Democratic candidates if a path to citizenship is opened. Even the most conservative guesses assume that Democrats would benefit more than Republicans, initially, at least.

Rubio's allies play it down.

"The status quo is not acceptable to Republican voters," said GOP consultant Kevin Madden, who has worked for Romney and others. Republican leaders, he said, must push for the best rewrite of immigration laws they can achieve.

Texas-based GOP consultant Matt Mackowiak noted that evangelical leaders, major business groups and others that opposed immigration changes in 2007 are now on board. He said the Republican Party should focus on attracting Hispanic voters with its standard message of small government and free enterprise, and not worry too much if a new law produces more Democratic-leaning voters for a while.

"If we don't win 40 to 45 percent of Hispanics," Mackowiak said, "we're not going to win elections regardless of whether this happens."

Limbaugh is among those who don't buy it.

"I see polling data again that suggests that 70 percent of the Hispanic population in the country believes that government is the primary source of prosperity," he told Rubio in their recent exchange. "I don't, therefore, understand this contention that Hispanics are conservatives-in-waiting."

___

Follow Charles Babington on Twitter: https://twitter.com/cbabington

Source: http://news.yahoo.com/immigration-bill-bad-deal-gop-132850249.html

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Gunmen surround foreign ministry in Libya capital | Morocco World ...

TRIPOLI, April 28, 2013 (AFP)

Gunmen surrounded Libya?s foreign ministry on Sunday demanding it be ?cleansed of agents? and ambassadors of ousted
dictator Moamer Kadhafi, an official said.

The group prevented staff from entering the building in Tripoli, said the ministry official who spoke to AFP on condition of anonymity.

Around 30 vehicles, some mounted with anti-aircraft guns, and dozens of armed men surrounded the office, an AFP photographer at the scene reported.

The official criticised the group?s ?extremely offensive? behaviour, even if their demands were ?legitimate?, saying this did not justify ?paralysing the whole work of a ministry?.

The General National Congress, Libya?s highest political authority, is studying proposals for a law to exclude former Kadhafi regime officials from top government and political posts.

The proposed law could affect several senior figures in the government, and has caused waves in the country?s political class.

In March, demonstrators encircled the assembly, trapping members in the building for several hours as they called for the adoption of the law.

After the siege was lifted, gunmen targeted Congress chief Mohammed Megaryef?s motorcade without causing any casualties.

Libya?s government is struggling to assert its influence across the country, where Megaryef?s militias who fought Kadhafi in the 2011 uprising still countrol much territory.

Source: http://www.moroccoworldnews.com/2013/04/88813/gunmen-surround-foreign-ministry-in-libya-capital/

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Friday, April 26, 2013

Amazon to release its own set-top box: Report

Amazon plans to put out a set-top box to compete with the likes of Roku, Apple TV, and other streaming devices, Bloomberg reported Wednesday. No price or timeline was mentioned, except that it would appear sometime in 2013.

The Seattle-based company has been diversifying its product catalog for years, and although it is best known for its all-encompassing online store, it now also offers web hosting, multimedia streaming, and an expanding line of Kindle-branded electronics.

A set-top box would be a natural fit with Amazon's existing products: More people than ever are signing up for streaming video and audio, and the success of the Kindle Fire has shown that Amazon-themed products can find success with electronics buyers at large.

The device is said to be under development in an Amazon research lab in Cupertino, where perennial competitor Apple is also based. It would likely be priced very competitively and offer extremely easy access to Amazon's media library, with the inevitable perks for Amazon Prime customers.

What will it be called? It's anyone's guess: Although "Kindle" is a contender, devices of that name have all been handheld ? tablets and e-readers. We'll find out when the product is announced later this year.

Devin Coldewey is a contributing writer for NBC News Digital. His personal website is coldewey.cc.

Source: http://feeds.nbcnews.com/c/35002/f/653377/s/2b20e35f/l/0L0Snbcnews0N0Ctechnology0Cgadgetbox0Camazon0Erelease0Eits0Eown0Eset0Etop0Ebox0Ereport0E6C9587298/story01.htm

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Thursday, April 25, 2013

Missing link in Parkinson's disease found: Discovery also has implications for heart failure

Apr. 25, 2013 ? Researchers at Washington University School of Medicine in St. Louis have described a missing link in understanding how damage to the body's cellular power plants leads to Parkinson's disease and, perhaps surprisingly, to some forms of heart failure.

These cellular power plants are called mitochondria. They manufacture the energy the cell requires to perform its many duties. And while heart and brain tissue may seem entirely different in form and function, one vital characteristic they share is a massive need for fuel.

Working in mouse and fruit fly hearts, the researchers found that a protein known as mitofusin 2 (Mfn2) is the long-sought missing link in the chain of events that control mitochondrial quality.

The findings are reported April 26 in the journal Science.

The new discovery in heart cells provides some explanation for the long known epidemiologic link between Parkinson's disease and heart failure.

"If you have Parkinson's disease, you have a more than two-fold increased risk of developing heart failure and a 50 percent higher risk of dying from heart failure," says senior author Gerald W. Dorn II, MD, the Philip and Sima K. Needleman Professor of Medicine. "This suggested they are somehow related, and now we have identified a fundamental mechanism that links the two."

Heart muscle cells and neurons in the brain have huge numbers of mitochondria that must be tightly monitored. If bad mitochondria are allowed to build up, not only do they stop making fuel, they begin consuming it and produce molecules that damage the cell. This damage eventually can lead to Parkinson's or heart failure, depending on the organ affected. Most of the time, quality-control systems in a healthy cell make sure damaged or dysfunctional mitochondria are identified and removed.

Over the past 15 years, scientists have described much of this quality-control system. Both the beginning and end of the chain of events are well understood. And since 2006, scientists have been working to identify the mysterious middle section of the chain -- the part that allows the internal environment of sick mitochondria to communicate to the rest of the cell that it needs to be destroyed.

"This was a big question," Dorn says. "Scientists would draw the middle part of the chain as a black box. How do these self-destruct signals inside the mitochondria communicate with proteins far away in the surrounding cell that orchestrate the actual destruction?"

"To my knowledge, no one has connected an Mfn2 mutation to Parkinson's disease," Dorn says. "And until recently, I don't think anybody would have looked. This isn't what Mfn2 is supposed to do."

Mitofusin 2 is known for its role in fusing mitochondria together, so they might exchange mitochondrial DNA in a primitive form of sexual reproduction.

"Mitofusins look like little Velcro loops," Dorn says. "They help fuse together the outer membranes of mitochondria. Mitofusins 1 and 2 do pretty much the same thing in terms of mitochondrial fusion. What we have done is describe an entirely new function for Mfn2."

The mitochondrial quality-control system begins with what Dorn calls a "dead man's switch."

"If the mitochondria are alive, they have to do work to keep the switch depressed to prevent their own self-destruction," Dorn says.

Specifically, mitochondria work to import a molecule called PINK. Then they work to destroy it. When mitochondria get sick, they can't destroy PINK and its levels begin to rise. Then comes the missing link that Dorn and his colleague Yun Chen, PhD, senior scientist, identified. Once PINK levels get high enough, they make a chemical change to Mfn2, which sits on the surface of mitochondria. This chemical change is called phosphorylation. Phosphorylated Mfn2 on the surface of the mitochondria can then bind with a molecule called Parkin that floats around in the surrounding cell.

Once Parkin binds to Mfn2 on sick mitochondria, Parkin labels the mitochondria for destruction. The labels then attract special compartments in the cell that "eat" and destroy the sick mitochondria. As long as all links in the quality-control system work properly, the cells' damaged power plants are removed, clearing the way for healthy ones.

"But if you have a mutation in PINK, you get Parkinson's disease," Dorn says. "And if you have a mutation in Parkin, you get Parkinson's disease. About 10 percent of Parkinson's disease is attributed to these or other mutations that have been identified."

According to Dorn, the discovery of Mfn2's relationship to PINK and Parkin opens the doors to a new genetic form of Parkinson's disease. And it may help improve diagnosis for both Parkinson's disease and heart failure.

"I think researchers will look closely at inherited Parkinson's cases that are not explained by known mutations," Dorn says. "They will look for loss of function mutations in Mfn2, and I think they are likely to find some."

Similarly, as a cardiologist, Dorn and his colleagues already have detected mutations in Mfn2 that appear to explain certain familial forms of heart failure, the gradual deterioration of heart muscle that impairs blood flow to the body. He speculates that looking for mutations in PINK and Parkin might be worthwhile in heart failure as well.

"In this case, the heart has informed us about Parkinson's disease, but we may have also described a Parkinson's disease analogy in the heart," he says. "This entire process of mitochondrial quality control is a relatively small field for heart specialists, but interest is growing."

This work was supported by the National Institutes of Health (NIH) grants R01 HL059888 and R21 HL107276.

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Story Source:

The above story is reprinted from materials provided by Washington University School of Medicine. The original article was written by Julia Evangelou Strait.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Y. Chen, G. W. Dorn. PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria. Science, 2013; 340 (6131): 471 DOI: 10.1126/science.1231031

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/QSYvGCfVQ78/130425142357.htm

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Deal of the Day ? Samsung 40? 120Hz LED Smart TV with a free $100 Gift Card

LogicBUY’s Deal for Wednesday is the 40″?Samsung Series 5 UN40EH5300 1080p 120Hz LED-backlit Smart HDTV bundled with a $100 Dell eGift card?for?$529.99. ?Features: Full HD 1080p Two 10W speakers Dolby Digital Plus/Dolby Pulse,?SRS TheaterSound HD Two HDMI, one USB (1), one component in, one optical digital audio output ConnectShare Movie Wide Color Enhancer Plus $679.99 [...]

Source: http://the-gadgeteer.com/2013/04/24/deal-of-the-day-samsung-40-120hz-led-smart-tv-with-a-free-100-gift-card/

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